Antitumor Immune Function of liver affected by the bacteria in liver, as scientists have found a connection between bacteria in the gut and antitumor immune responses in the liver. The study published by researchers in the Center for Cancer Research at the National Cancer Institute.
The findings have indication for understanding the mechanisms that lead to liver cancer and for therapeutic approaches to treat them. NCI is part of the National Institutes of Health.
“What we found using different tumor models is that if you treat mice with antibiotics and thereby deplete certain bacteria, you can change the composition of immune cells of the liver, affecting tumor growth in the liver,” said Tim Greten, M.D., of NCL’s CCR.
The microbiome is the collection of bacteria and other microorganisms that live in or on the body. In humans, the greatest proportion of the body’s total microbiome is in the stomach.
Dr. Greten and his team carried out a series of experiments with mice. They used three mouse models of liver cancer. The investigators next studied the immune cells in the liver to understand how the reduction of gut bacteria suppressed tumor growth in the liver of the antibiotic-treated mice.
Antibiotic treatment increased the numbers of NKT cells in the livers of the mice. They found an increase in the expression of a protein called CXCL16 on cells. Finally, the investigators found that one bacterial species, Clostridium scindens which controls metabolism of bile acids in the mouse gut.